Lisa Fong-Poh NG
Adjunct Associate Professor
Adjunct Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Senior Principal Investigator, Singapore Immunology Network, A*STAR.
Lisa’s scientific expertise and the close cooperation with colleagues, clinicians and field workers has allowed her to provide major contribtions in the containment, prevention and treatment of epidemic viral infections including SARS (Severe Acute Respiratory Syndrome) and avian influenza H5N1 (bird flu). Chikungunya virus is a re-emerging arbovirus that causes dengue fever-like symptoms coupled with debilitating chronic joint pain. The virus has now severely swept over several countries in Inaid, South-East Asia, including Singapore and more recently in the Americas, infected more than 2 million people since 2006. Lisa is currently a Principal Investigator, leading a research team at the Singapore Immunology Network (SIgN). Her research focuses on the immune responses of arthrogenic arboviruses that are epidemic or highly endemic in the tropical region with a strong focus on Chikungunya virus. Her team has published in top tier scientific journals and made several key important findings to move the human immunology field forward in controlling the rising number of Chikungunya virus infections. For her contributions, she was voted “Most Inspiring Woman” at the Great Women of Our Time Awards for Science and Technology in 2005, and was confered the Junior Chamber International (JCI) “Ten Outstanding Young Persons of the World” Singapore 2013 Scientific and/or Technological Development Award. For her meritorious research and development efforts on Asia’s infectious diseases, she was conferred the highly prestigious ASEAN (Association of South-East Asian Nations) “International Young Scientist and Technologist Award” in 2008.
Lisa F.P. Ng’s laboratory focuses on:
1. Pathogenesis in humans
2. Pathogenesis in murine models
3. Analysis of virus-cell interactions and study of innate immune responses against virus infections
4. Development of immune-based control strategies
- Teng TS, Kam YW, Lee B, Hapuarachchi HC, Wimal A, Ng LC, Ng LFP (2015) “A Systematic Meta-analysis of Immune Signatures in Acute Chikungunya Virus-infected Patients” J Infect Dis Jan 29. pii: jiv049. [Epub ahead of print].
- Hallengärd D, Lum FM, Kümmerer BM, Lulla A, Lulla García-Arriaza J, Fazakerley J, Roques P, Le Grand R, Merits A, Ng LFP, Esteban M, Liljeström P (2014) “Prime-boost immunization strategies against Chikungunya virus” J Virol 88:13333-43.].
- Her Z, Teng TS, Teo TH, Tan JJL, Lum FM, Gabriel C, Lee WWL, Kam YW, Lulla V, Lulla A, Merits A, Leo YS, Rénia L, Ng LFP (2014) “TLR3 restricts CHIKV replication and protects against CHIKV-induced pathology” EMBO Mol Med 7:24-41.].
- Herrero LJ, Sheng KC, Jian P, Taylor A, Her Z, Herring BL, Chow A, Leo YS, Hickey MJ, Morand EF, Ng LFP, Bucala R, Mahalingam S (2013) “Macrophage migration inhibitory factor receptor CD74 mediates alphavirus-induced arthritis and myositis in murine models of alphavirus infection” Arthritis Rheum 65:2724-2736.].
- Lum FM, Teo TH, Lee WWL, Kam YW, Rénia L, Ng LFP (2013)“An essential rôle of antibodies in the control of Chikungunya virus infection” J Immunol 190:6295-6302.].
- Teo TH, Lum FM, Claser C, Lulla V, Lulla A, Merits A, Rénia L, Ng LFP (2013) “A pathogenic role for CD4+ T cells during Chikungunya infection in mice” J Immunol 190:259-69.].