YONG Kol Jia

Senior Tutor

+65 6516 1139
bchykj@nus.edu.sg

Affiliations

Senior Tutor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS
Research Scientist, Cancer Science Institute, NUS

Education

Degree and Institution Year(s)
Ph.D, NUS Graduate School for Integrative Sciences and Engineering, Singapore 2009-2013
B.Sc. (Hons), National University of Singapore, Singapore 2004-2008

Professional Experience

Title Year(s)
Senior tutor, Department of Biochemistry, Yong Loo Lin School of Medicine & Cancer Science Institute of Singapore, National University of Singapore, Singapore 2018–present
Research scholar, University of California, San Francisco, USA 2016–2018
Research Fellow, Cancer Science Institute of Singapore, Singapore 2013–2016

Research Interest

Studying the complex gene regulatory network by identifying and characterizing cis and trans elements in gene regulation

Current Research Projects

  1. Investigating the mechanisms of oncofetal protein SALL4 in cancers
  2. High-throughput screen for novel gene expression regulators
  3. Exploring the roles of long non-coding RNAs (lncRNAs) in cancers

Selected Publications

  1. Yong, K.J.*, Basseres, D.S.*, Welner, R.S., Zhang, W.C., Yang, H., Yan, B., Alberich-Jorda, M., Zhang, J., de Figueiredo-Pontes, L.L., Battelli, C., Hetherington, C.J., Ye, M., Zhang, H., Maroni, G., O'Brien, K., Magli, M.C., Borczuk, A.C., Varticovski, L., Kocher, O., Zhang, P., Moon, Y.C., Sydorenko, N., Cao, L., Davis, T.W., Thakkar, B.M., Soo, R.A., Iwama, A., Lim, B., Halmos, B., Neuberg, D., Tenen, D.G., Levantini, E. (2016) Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression. Sci Transl Med 8, 350ra104. *Equal contribution

  2. Yong ,K.J.*, Li, A.*, Ou, W.B.*, Hong, C.K., Zhao, W., Wang, F., Tatetsu, H., Yan, B., Qi, L., Fletcher, J.A., Yang, H., Soo, R., Tenen, D.G., Chai, L. (2016). Targeting SALL4 by entinostat in lung cancer. Oncotarget 7, 75425-75440. *Equal contribution

  3. Yong, K. J., Gao, C., Lim, J. S., Yan, B., Yang, H., Dimitrov, T., Kawasaki, A., Ong, C. W., Wong, K. F., Lee, S., et al. (2013). Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med 368, 2266-2276.

  4. Li, A., Jiao, Y.,Yong, K. J., Wang, F., Gao, C., Yan, B., Srivastava, S., Lim, G.S., Tang, P., Yang, H., et al. (2013). SALL4 is a new target in endometrial cancer. Oncogene.

  5. Gao, C., Dimitrov, T.,Yong, K. J., Tatetsu, H., Jeong, H. W., Luo, H. R., Bradner, J. E., Tenen, D. G., and Chai, L. (2013). Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. Blood 121, 1413-1421.

  6. Chan, T. H., Lin, C. H., Qi, L., Fei, J., Li, Y.,Yong, K. J., Liu, M., Song, Y., Chow, R. K., Ng, V. H., et al. (2013). A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma. Gut.

  7. Yan, B., Lim, M., Zhou, L., Kuick, C. H., Leong, M. Y.,Yong, K. J., Aung, L., Salto-Tellez, M., and Chang, K. T. (2013). Identification of MET genomic amplification, protein expression and alternative splice isoforms in neuroblastomas. J Clin Pathol.

  8. Yan, B., Choo, S.N., Mulyadi, P., Srivastava, S., Ong, C.W.,Yong, K.J., Putti, T., Salto-Tellez, M., and Lim, G.S. (2011). Dual-colour HER2/chromosome 17 chromogenic in situ hybridisation enables accurate assessment of HER2 genomic status in ovarian tumours. J Clin Pathol 64, 1097-1101.

  9. Yan, B., Yau, E.X., Choo, S.N., Ong, C.W., Yong, K.J., Pang, B., and Salto-Tellez, M. (2011). Dual-colour HER2/chromosome 17 chromogenic in situ hybridisation assay enables accurate assessment of HER2 genomic status in gastric cancer and has potential utility in HER2 testing of biopsy samples. J Clin Pathol 64, 880-883.

  10. Yan, B., Yau, E.X., Samanta, S., Ong, C.W., Yong, K.J., Ng, L.K., Bhattacharya, B., Lim, K.H., Soong, R., Yeoh, K.G., et al. (2011). Clinical and therapeutic relevance of PIM1 kinase in gastric cancer. Gastric Cancer.

  11. Yong, K.J., and Yan, B. (2011). The relevance of symmetric and asymmetric cell divisions to human central nervous system diseases. J Clin Neurosci 18, 458-463.