TAN Tin Wee

Associate Professor


Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Chairman, Computational Resource Centre (ACRC), A*STAR.
Board Director, Keppel Telecommunications & Transportation.
Director, National Supercomputing Centre.
Nominee Director, Asia Pacific Bioinformatics Network (APBionet) Ltd.
Director, Knorex Pte Ltd.
Director, iGates BioInnovation Pte Ltd (a joint venture of KOOPrime Pte Ltd and Eu Yan Sang International Ltd).
Member, International Conference on Bioinformatics (InCoB) Steering Committee.
Member, Academic Advisory Committee, MDIS.
Member, Life Science Advisory Committee, Nanyang Polytechnic.
Member, Scientific Advisory Committee, Link THM Sciences Pte Ltd.


Degree and Institution Year(s)
PhD, Molecular Biology, The University of Edinburgh 1986-1990
MSc (wit Distinction), Applied Molecular Biology and Biotechnology, University College London, UK. 1985–1986
BA, Natural Sciences Tripos (Biochemistry), University of Cambridge, UK 1982-1985

Professional Experience

Position and Institute Year(s)
Acting Head, Dept. of Biochemistry, Faculty of Medicine, National University of Singapore. 2011–2012
Associate Professor, Dept. of Biochemistry, Faculty of Medicine, National University of Singapore 1999-present
Director, The International Centre for Disability Resources on the Internet, Singapore 1999–present
Associate Director, Centre for Internet Research, NUS 1998–present
Special Advisor to Director-General, Asia Pacific Network Information Center (APNIC) - Internet Addresses and Numbers for AP Region, Singapore 1998-1999
Co-Director, User Community Area, Asia Pacific Advanced Network (APAN) Consortium - Advancing high performance networking in AP region, Singapore 1997–present
South East Asian Representative, Coordinating Committee for InterContinental Research Networking (CCIRN), Singapore 1997–present
Founding Non-executive director, Bioinformatrix Pte Ltd -An NUS Spin-off Company, Singapore 1997–2001
Chairman, Asia Pacific Networking Group (APNG), Singapore 1997-1999
Advisor to SingCERT Incident response and Internet Security for Singapore Telemanufacturing Research Group Pioneering remote rapid prototyping Satellite Internet Competency Unit Advancing satellite internet technology 1997–1999
Chairman, CAL Project, IT Task Force for Special Education Schools, National Council for Social Service, Singapore 1997-1998
Principal Investigator and Founder, Singapore Advanced Research and Education Network (SINGAREN), Singapore 1997
Co-Chairman, Enable2000 virtual committee for Internet among people with disabilities, Singapore 1996-present
Director, Bioinformatics Centre, National University of Singapore (NUS) 1996–2001
President, Association for Informatics in Medicine Singapore (AIMS), SIngapore 1996-2000
Consultant, ASEAN Science and Technology Information Network (ASTNET) Project, Singapore 1996-1997
Head, Internet Research and Development Unit; Assistant Director, Computer Centre, NUS; Upgraded into Centre for Internet Research 1995-1998
Consultant, National Technology Databank, Singapore 1995–1997
Head, Technet Unit, NUS; commercialised into Pacific Internet 1994–1995
Coordinator, EDB-NUS Biotechnology Database, Singapore 1993–1996
Consultant, Education Sector, Schools Internet Pilot Project, National Computer Board, Singapore 1993-1994
Resident Fellow, Sheares Hall of Residence, NUS 1992-1996
Coordinator, Biocomputing Research and User Support technology group, Singapore 1992–1996
Lecturer/Senior Lecturer, Dept of Biochemistry, Faculty of Medicine, NUS 1990–1995
Research Fellow, Animal Health Trust, UK 1986–1989

Research Interest

Current research areas include multilingualisation of Internet, music notation on the Internet, Internet communication protocols, VRML, Java, advanced Internet technologies, building regional advanced research networks, biocomputing and bioinformatics. In straddling two major technologies, IT and Biotechnology, he hopes to help Singapore establish a niche as a major technology player in Bioinformatics.

* Bioinformatics
* Advanced Internet Network Protocols and Applications in Biological Sciences

In particular, we are pursuing the following projects:
1) Biodatabases; Large-scale workflow integration; grid computing; immunomics & vaccine informatics.
2) Computer protocols, applications and standards for biological entities, nomenclature, pathways, diagramming and software tools interfacing.
3) Advanced Internet research network engineering for bioinformatics applications.
4) Internet protocols for bioinformatics and multilingual internet names.

Selected Publications

  1. Lim SJ, Khan AM, Silva MD, Lim KS, Hu Y, Tan CH, Tan TW. The implementation of e-learning tools to enhance undergraduate bioinformatics teaching and learning: a case study in the National University of Singapore. BMC Bioinformatics. 2009, 10(Suppl 15):S12.

  2. Koo QY, Khan AM, Jung KO, Ramdas S, Miotto O, Tan TW, Brusic V, Salmon J, August JT. Conservation and variability of West Nile virus proteins. PLoS One. 2009;4(4):e5352. Epub 2009 Apr 29.

  3. Ranganathan S, Hsu WL, Yang UC, Tan TW. Emerging strengths in Asia Pacific bioinformatics. BMC Bioinformatics. 2008 Dec 12;9 Suppl 12:S1.

  4. Khan AM, Miotto O, Nascimento EJ, Srinivasan KN, Heiny AT, Zhang GL, Marques ET, Tan TW, Brusic V, Salmon J, August JT. Conservation and variability of dengue virus proteins: implications for vaccine design. PLoS Negl Trop Dis. 2008 Aug 13;2(8):e272.

  5. Miotto O, Heiny AT, Tan TW, August JT, and Brusic V. Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis. BMC Bioinformatics 2008, 9(Suppl 1): S18. doi:10.1186/1471-2105-9-S1-S18

  6. Sangket U, Phongdara A, Chotigeat W, Nathan D, Kim WY, Bhak J, Ngamphiw C, Tongsima S, Khan AM, Lin H, Tan TW. Automatic synchronization and distribution of biological databases and software over low-bandwidth networks among developing countries. Bioinformatics 2008 24 (2):299-301.

  7. Miotto O, Tan TW, Brusic V. Rule-based Knowledge Aggregation for Large-Scale Protein Sequence Analysis of Influenza A Viruses. BMC Bioinformatics 2008, 9(Suppl 1): S7. doi:10.1186/1471-2105-9-S1-S7

  8. Ranganathan S, Gribskov M, Tan TW. Bioinformatics research in the Asia Pacific: a 2007 update. BMC Bioinformatics. 2008;9 Suppl 1:S1.

  9. Tong JC, Zhang ZH, August JT, Brusic V, Tan TW and Shoba Ranganathan. In silico characterization of immunogenic epitopes presented by HLA-Cw*0401 Immunome Research 2007, 3:7 (20 Aug 2007)

  10. Wee LJK, Tan TW, Ranganathan S. CASVM: web server for SVM-based prediction of caspase substrates cleavage sites. Bioinformatics 2007, 23: 3241-3243.

  11. Heiny AT, Miotto O, Srinivasan KN, Khan AM, Zhang GL, Brusic V, Tan TW, August JT. Evolutionarily Conserved Protein Sequences of Influenza A Viruses, Avian and Human, as Vaccine Targets. PLoS ONE 2007, 2(11):e1190.

  12. Tong JC, Tan TW, Ranganathan S. In silico grouping of peptide/HLA class I complexes using structural interaction characteristics. Bioinformatics 2007 Jan 15;23(2):177-83.

  13. Tong JC, Tan TW, Ranganathan S. Methods and protocols for prediction of immunogenic epitopes. Briefings in Bioinformatics 2007; doi: 10.1093/bib/bbl038

  14. Bollina D, Lee BT, Tan TW, Ranganathan S. ASGS: an alternative splicing graph web service. Nucleic Acids Res. 2006 Jul 1;34 (Web Server issue):W444-7.

  15. Khan AM, Miotto O, Heiny AT, Salmon J, Srinivasan KN, Nascimento EJ, Marques ET Jr, Brusic V, Tan TW, August JT. A systematic bioinformatics approach for selection of epitope-based vaccine targets. Cell Immunol 2006, 244 (2), 141-147

  16. Khan AM, Heiny AT, Lee KX, Srinivasan KN, Tan TW, August JT, Brusic V. Large-scale analysis of antigenic diversity of T-cell epitopes in dengue virus. BMC Bioinformatics 2006, 7(Suppl 5):S4

  17. Wee LJK, Tan TW and Ranganathan S. SVM-based prediction of caspase substrate cleavage sites. BMC Bioinformatics 2006, 7(Suppl 5):S14

  18. Tong JC, Kong L, Tan TW, Ranganathan S. MPID-T: Database for Sequence-Structure-Function Information on T-Cell Receptor/Peptide/MHC Interactions. Appl Bioinformatics 2006; 5 (2): 111-114.

  19. Tong JC, Tan TW, Sinha AA and Ranganathan S. Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris. BMC Bioinformatics 2006, 7(Suppl 5):S7

  20. Tong JC, Zhang GL, Tan TW, August JT, Brusic V, Ranganathan S. Prediction of HLA-DQ3.2beta Ligands: evidence of multiple registers in class II binding peptides. Bioinformatics 2006, 22(10):1232-1238.