CHANG Matthew Wook

Associate Professor


Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS
Director, Wilmar-NUS Corporate Laboratory (Wil@NUS)
Director, Singapore Consortium for Synthetic Biology (SINERGY)
Director, NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI)
Lead, NUHS Summit Research Programme, Synthetic Biology (SRP)


Matthew Chang has made contributions in the field of synthetic biology. His research interests lie in the development of biological systems that perform programmable functions. His work has received international recognitions and has been featured in leading media outlets worldwide. He has been honored with the Scientific and Technological Achievement Award from U.S. Environmental Protection Agency. He serves as an editor and an editorial board member for a number of journals including Cell Systems, ACS Synthetic Biology, Biotechnology for Biofuels, Metabolic Engineering, and Critical Reviews in Microbiology. He serves on the advisory committee of key international research programs such as the Synthetic Biology Open Language (SBOL), Chinese National GeneBank and CSIRO Future Science Platform. He is a strong advocate of promoting interdisciplinary science that marries engineering, biological, medical and social sciences through education and public science outreach.

Research Interest

Reprogramming biological functionalities for energy, healthcare and environmental applications

Selected Publications

  1. Foo JL, Chang MW* (2018) Synthetic yeast genome reveals its versatility. Nature 557:647-648.

  2. Ho CL, Tan HQ, Chua KJ, Kang A, Lim KH, Ling LK, Yew WS, Lee YS, Thiery JP, Chang MW* (2018) Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention. Nature Biomedical Engineering. 2.27-37.

  3. Lubkowicz D; Ho CL; Hwang IY; Yew WS; Lee YS; Chang MW* (2018) Reprogramming probiotic Lactobacillus reuteri as a biosensor for Staphylococcus aureus derived AIP-I detection. ACS Synthetic Biology. 7:1229-1237

  4. Pham HL, Wong A, Chua N, Teo WS, Yew WS, Chang MW* (2017) Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes. Nature Communications. 8:411.

  5. Hwang IY, Koh E, Wong A, March JC, Bentley WE, Lee YS, Chang MW* (2017) Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models. Nature Communications. 8:15028.