Matthew Wook CHANG

Associate Professor


Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Director, Singapore Consortium for Synthetic Biology (SINERGY).
Director, NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI).


Matthew Chang has made contributions in the field of synthetic biology. His research interests lie in the development of biological systems that perform programmable functions. His work has received international recognition and is featured in leading media outlets worldwide. He has been honored with the Scientific and Technological Achievement Award from U.S. Environmental Protection Agency. He serves as an editor for Biotechnology for Biofuels, IET Synthetic Biology, Applied Biochemistry and Biotechnology, and Critical Reviews in Microbiology, and as an editorial board member for Biotechnology Journal, ACS Synthetic Biology and Cell Systems. He serves on the international advisory panel of the Synthetic Biology Open Language (SBOL), an open standard designed to facilitate the exchange and storage of genetic designs. He is a strong advocate of promoting interdisciplinary science that marries engineering, biological, medical and social sciences through primary, secondary and tertiary education, and public science outreach.

Research Interest

1. Microbiome engineering for prevention and treatment of human diseases.
2. Functional probiotics as advanced dietary supplements.
3. Engineering biology for production of value-added chemicals.

Selected Publications

  1. Pham HL, Wong A, Chua N, Teo WS, Yew WS, and Chang MW (2017) Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes. Nature Communications. 8:411

  2. Hwang IY, Koh E, Wong A, March JC, Bentley WE, Lee YS, and Chang MW (2017) Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models. Nature Communications. 8:15028

  3. Pham HL, Ho CL, Wong A, Lee YS, and Chang MW (2017) Applying the design-build-test paradigm in microbiome engineering. Current Opinion in Biotechnology. 48:85–93

  4. Hwang IY, Koh E, Kima HR, Yew WS, Chang MW (2016) Reprogrammable microbial cell-based therapeutics againstantibiotic-resistant bacteria Drug Resistance Updates. 27 59–71

  5. Lo T, Chng SH, Teo WS, Cho HS, Chang MW (2016) A Two-Layer Gene Circuit for Decoupling Cell Growth from Metabolite Production. Cell Systems. 3:133-143.