Robert Charles ROBINSON

Adjunct Associate Professor

Affiliations

Adjunct Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Program Director, Institute of Molecular & Cell Biology, A*STAR.

Education

Degree and Institution Year(s)
PhD, Oxford University, UK 1996
Master, University of British Columbia, Canada 1990
Bachelor, King's College, London University, UK 1987

Professional Experience

Position and Institute Year(s)
X-ray Facility Supervisor, Institute of Molecular & Cell Biology, A*STAR 2010 - Present
Co-founder, Singapore Biophysical Society, Singapore 2010 - Present
Reviewer, SNAS Young Scientist Award, Singapore 2010 - Present
Member, NUS Graduate School for Integrative Sciences and Engineering (NGS) PhD Thesis Committee, Singapore 2010 - Present
Supervisors, NUS Graduate School for Integrative Sciences and Engineering (NGS), NUS 2007 - Present
Equipment Committee Chairman, Institute of Molecular & Cell Biology, A*STAR 2007 - Present
Space Committee Member, Institute of Molecular & Cell Biology, A*STAR 2007 - 2007
Judge, A*STAR Talent Search Final, A*STAR 2007 - 2008
Purchasing Committee Member, Institute of Molecular & Cell Biology, A*STAR 2007 - 2009
Grant Reviewer, BMRC, Singapore 2006 - Present
Senior Lektor, IMBIM, Uppsala University, Sweden 2001 - 2005
Postdoctoral, The Salk Institute for Biological Studies, USA 1996 - 2001
Research Assistant, Regeneron Pharmaceuticals, USA 1991 - 1992

Research Interest

* How the force generated by actin polymerization is integrated to drive biological processes.
* The variation in filament design for actin-like proteins from pathogens.
* Cell movement.
* Structural biology – Protein crystallography and electron microscopy.

Selected Publications

  1. Hernandez-Valladares, M., Kim, T., Kannan, B., Tung, A., Aguda, A. H., Larsson, M, Cooper, J. A. & Robinson, R. C. Structural characterization of a capping protein interaction motif defines a family of actin filament regulators. Nat. Struct. Mol. Biol. (2010) 17, 497-503.

  2. Chumnarnsilpa, S., Lee, W. L., Nag, S., Kannan, B., Larsson, M., Burtnick, L. D. & Robinson, R. C. The crystal structure of the C-terminus of adseverin reveals the actin-binding interface. PNAS (2009) 106, 13719-13724.

  3. Nag, S., Ma, Q., Wang, H., Chumnarnsilpa, S., Lee, W. L., Larsson, M., Kannan, B., Hernandez-Valladares, M., Burtnick, L. D. & Robinson, R. C. Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin. PNAS (2009) 106, 13719-13724.

  4. Aguda, A. H., Xue, B., Irobi, E., Preat, T. & Robinson, R. C. The structural basis of actin interaction with multiple WH2 motif-containing proteins. Structure. (2006) 14, 469-476.

  5. Huang, S., Robinson, R. C., Gao, L. Y., Matsumoto, T., Brunet, A., Blanchoin, L. & Staiger, C. J. Arabidopsis VILLIN1 generates actin filament cables that are resistant to depolymerization. Plant Cell (2005) 17, 486-501.

  6. Irobi, E., Aguda, A. H., Larsson, M., Guerin, C., Yin, H. L., Burtnick, L. D., Blanchoin, L. & Robinson, R. C. Structural basis of actin sequestration by thymosin-β4: Implications for WH2 proteins. EMBO J. (2004) 23, 3599-3608.

  7. Burtnick, L. D., Urosev, D., Irobi, E., Narayan, K. & Robinson, R. C. Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF. EMBO J. (2004) 23, 2713-272.

  8. Robinson, R. C., Turbedsky, K., Kaiser, D. A., Higgs, H., Marchand, J.-B. Choe, S. & Pollard, T. D. Crystal Structure of Arp2/3 Complex. Science. (2001) 294, 1679-1684.

  9. Robinson, R. C., Mejillano, M., Le, V. P., Burtnick, L. D., Yin, H. L. & Choe, S. Domain movement in a gelsolin activation switch. Science (1999) 286,1939-1942.