Adjunct Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Principal Investigator, Institute of Molecular & Cell Biology, A*STAR.
Supervisors, NUS Graduate School for Integrative Sciences and Engineering (NGS), NUS.
|Degree and Institution||Year(s)|
|PhD, Institute of Molecular & Cell Biology, A*STAR||1993|
PRL-1 (Phosphatase induced in Regenerating Liver) was identified in 1994 as a gene up-regulated during liver regeneration after partial hepatectomy. We identified PRL-2 & PRL-3 and demonstrated that PRL-1, PRL-2 and PRL-3 are membrane-associated through lipid modification termed prenylation. Among all the human protein tyrosine phosphatases (PTPs), only PRL-1, PRL-2 and PRL-3 are prenylated and represent an oncogenic PRL-family associated with multiple human cancers. Genomic studies have revealed that PRL-3 is a metastasis-associated phosphatase because it is consistently over-expressed in metastatic colorectal cancer cells (CRC). We have been focusing on the role of PRL-3 and its underlying molecular mechanism in cancer development, progression, and metastasis. We generated specific mouse monoclonal antibodies against PRL-3 and PRL-1, which allowed us to examine their expression in various human cancers. PRL-3 is clearly overexpressed in a variety of cancers. PRL-3 promotes cell migration, invasion and metastasis, partly through its role in promoting Epithelial-Mesenchymal Transition. PRL-3 may initiate tumor angiogenesis as PRL-3 expressing cells are able to recruit endothelial cells. Recent work on PRL-3 phosphatase will also be discussed.
- Wang, H., Vardy, L., Tan, C.P., Loo, J.M., Guo, K., Li, J., Lim, S.G., Zhou, J., Chng, W.J., Ng, S.B., Li, H.X., and Zeng, Q. (2010) PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase. Cancer Cell 18, 52-62, July 13.
- Tang, J.P., Tan, C.P., Li, J., Siddique, M.M., Guo, K., Chan, S.W., Park, J.E., Tay, W.N., Huang, Z.Y., Li, W.C., Chen, J., and Zeng, Q. (2010) VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers. Molecular Cancer 9:128.
- Zeng Q. and W. Hong (2008) The emerging role of the Hippo pathway in cell contact inhibition, organ size control and cancer development in mammals (mini-review). Cancer Cell 13; 188-192.
- Guo, K., Li, J., Tang, J.P., Tan, C.P., Wang, H., and Zeng Q. (2008) Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice. Cancer Biology & Therapy 7:752-759.
- Basak, S., Jacobs, S.B., Krieg, A.J., Pathak, N., Zeng Q., Kaldis, P., Giaccia, A.J., Attardi, L.D. (2008) The metastasis-associated gene Prl-3 is a p53 target involved in cell cycle regulation. Molecular Cell 30:303-314.