Philipp KALDIS

Adjunct Associate Professor

Affiliations

Adjunct Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Senior Principal Investigator, Institute of Molecular and Cell Biology (IMCB)

Biodata

Philipp Kaldis received his PhD from the Institute for Cell Biology, ETH (Swiss Federal Institute of Technology), Zürich, Switzerland, in 1994 where he worked on the mitochondrial creatine kinase with Dr. Theo Wallimann and Dr. Hans Eppenberger. In 1995, he joined Dr. Mark Solomon’s laboratory at Yale University School of Medicine, Department of Molecular Biophysics and Biochemistry, New Haven, Connecticut, as a postdoctoral fellow/associate research scientist to investigate the activation of cyclin-dependent kinases (Cdks). In 2000, Dr. Kaldis joined the National Cancer Institute (NCI-Frederick) as tenure-track investigator and was promoted to senior investigator with tenure in 2006. In 2007, he joined the IMCB as senior principal investigator and adjunct associate professor at the department of Biochemistry NUS.

Research Interest

Research in my laboratory concentrates on the genetic interactions between regulators of the cell cycle in normal development and in cancer. We use the mouse as model systems to determine the in vivo functions of cyclin-dependent kinases (Cdks) and their regulators. Most projects are done in collaboration with laboratories all over the world. Current projects include:

a) Analysis of Cdk1 functions in vivo and in vitro
b) Study of liver regeneration and cancer
c) Coupling of cell cycle regulation and metabolism in the liver
d) Function of Cdk2 in fertility and meiosis
e) The role of cell cycle regulation in hematopoiesis and erythropoiesis
f) Coupling of cell cycle and differentiation in neuronal stem cells

Selected Publications

  1. Adhikari, D., Diril, M.K., Busayavalasa, K., Risal, S., Nakagawa, S., Lindkvist, R., Shen, Y., Coppola, V., Tessarollo, L., Kudo, N.R., Kaldis, P.*, and Liu, K.* (2014) Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II. J. Cell Biol., 206(7), 843-853. Commentary in Faculty of 1000: Commentary

  2. Gopinathan, L., Tan, S.L.W., Padmakumar, V.C., Coppola, V., Tessarollo, L., and Kaldis, P. (2014) Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis. Cancer Research, 74, 3870-3879.

  3. Miettinen, T.P., Pessa, H.K.J., Caldez, M.J., Fuhrer, T., Diril, M.K., Sauer, U., Kaldis, P., and Björklund, M. (2014) Identification of transcriptional and metabolic programs related to mammalian cell size. Curr. Biol., 24, 598-608.

  4. Jayapal, S.R. and Kaldis, P. (2014) p57Kip2 regulates T cell development and lymphoma. Blood, 123, 3370-3371.

  5. Lim, S. and Kaldis, P. (2013) Cdks, cyclins, and CKIs: roles beyond cell cycle regulation. Development, 140, 3079-3093.

  6. Lim, S. and Kaldis, P. (2012) Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells. Stem Cells, 30, 1509-1520.

  7. Diril, M.K., Ratnacaram, C.K., Padmakumar, V.C., Du, T., Wasser, M., Coppola, V., Tessarollo, L., and Kaldis, P. (2012) Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc. Natl. Acad. Sci. USA, 109, 3826-3831.

  8. Kaldis, P. and Richardson, H. E. (2012) When cell cycle meets development. Development, 139, 225 230.

  9. Virshup, D.M. and Kaldis, P. (2010) Enforcing the Greatwall in Mitosis. Science, 330, 1638-1639.

  10. Satyanarayana, A. and Kaldis, P. (2009) Mammalian cell cycle regulation: several Cdks, numerous cyclins, and diverse compensatory mechanisms. Oncogene, 28, 2925-2939.

  11. Kaldis, P. (2007) Another piece of the p27Kip1 puzzle. Cell, 128, 241 244.

  12. Berthet, C., Klarmann, K.D., Hilton, M.B., Suh, H.C., Keller, J.R., Kiyokawa, H., and Kaldis, P. (2006) Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Developmental Cell, 10, 563 573.

  13. Aleem, E., Kiyokawa, H., and Kaldis, P. (2005) Cdc2/cyclin E complexes regulate G1/S phase transition. Nature Cell Biology, 7, 831 836.

  14. Kaldis, P. (2005) The N terminal peptide of the KSHV cyclin determines substrate specificity. J. Biol. Chem., 280, 11165-11174.

  15. Berthet, C.*, Aleem, E.*, Coppola, V., Tessarollo, L., and Kaldis, P. (2003) Cdk2 knockout mice are viable. Current Biology, 13, 1775-1785.