Oi Lian KON

Honorary Joint Professor

+65 6436 8307
dmskol@nccs.com.sg

Affiliations

Honorary Joint Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Division Head (Medical Sciences), National Cancer Centre Singapore.

Research Interest

Gastric cancer Cell therapy of metabolic diseases.

Selected Publications

  1. Tao J, Deng NT, Ramnarayanan K, Huang B, Oh HK, Leong SH, Lim SS, Tan IB, Ooi CH, Wu J, Lee M, Zhang S, Rha SY, Chung HC, Smoot DT, Ashktorab H, Kon OL, Cacheux V, Yap C, Palanisamy N, Tan P. CD44-SLC1A2 gene fusions in gastric cancer. Science Translational Medicine 2011;3:77ra30.

  2. Guo T, Lee SS, Ng WH, Zhu Y, Gan CS, Zhu J, Wang H, Huang S, Sze SK, Kon OL. Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome. Cellular and Molecular Life Sciences 2011;68:1983-2002.

  3. Guo T, Zhu Y, Gan CS, Lee SS, Zhu J, Wang H, Li X, Christensen J, Huang S, Kon OL, Sze SK. Quantitative proteomics discloses MET expression in mitochondria as a direct target of MET kinase inhibitor in cancer cells. Molecular & Cellular Proteomics 2010;9:2629-2641.

  4. Chen NKF, Tan SY, Udolph G, Kon OL. Insulin expressed from endogenously active glucose-responsive EGR1 promoter in bone marrow mesenchymal stromal cells as diabetes therapy. Gene Therapy 2010;17:592-605.

  5. Sivalingam J, Krishnan S, Ng WH, Lee SS, Phan TT, Kon OL. Biosafety assessment of site-directed transgene integration in human umbilical cord-lining cells. Molecular Therapy 2010;18:1346-1356.

  6. Li GD, Luo R, Zhang J, Yeo KS, Xie F, Tan KWE, Caille D, Que J, Kon OL, Salto-Tellez M, Meda P, Lim SK. Derivation of functional insulin-producing cell lines from primary mouse embryo culture. Stem Cell Research 2009;2:29-40.

  7. Meng W, Zhang H, Guo T, Pandey C, Zhu Y, Kon OL, Sze SK. One-step procedure for peptide extraction from in-gel digestion sample for mass spectrometric analysis. Analytical Chemistry 2008;80:9797-9805.

  8. Guo T, Gan CS, Zhang H, Zhu Y, Kon OL, Sze SK. Hybridization of pulsed-Q dissociation and collision-activated dissociation in linear ion trap mass spectrometer for iTRAQ quantitation. Journal of Proteome Research 2008;7(11):4831-4840.

  9. Kon OL, Yip TT, Ho MF, Chan WH, Wong WK, Tan SY, Ng WH, Kam SY, Eng AKH, Ho P, Viner R, Ong HS, Kumarasinghe MP. The distinctive gastric fluid proteome in gastric cancer reveals a multi-biomarker diagnostic profile. BMC Medical Genomics (2008) 1:54.

  10. Chen NKF, Wong JS, Kee IH, Lai SH, Thng CH, Ng WH, Ng RT, Tan SY, Lee SY, Tan ME, Sivalingam J, Chow PK, Kon OL (2008) Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model. PLoS One 2008;3(3):e1734.