Haiwei SONG

Adjunct Professor

Affiliations

Adjunct Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Research Director, Institute of Molecular and Cell Biology, A*STAR.
Adjunct Associate Professor, Department of Biological Sciences, Faculty of Sciences, NUS.

Education

Degree and Institution Year(s)
PhD, School of Biochemistry and Molecular Biology, University of Leeds, UK. 1998
M.Sc, Institute. of Biophysics, Academia Sinica, China 1990
B.Sc. Dept. of Chemistry, Henan University, China. 1987

Professional Experience

Position and Institute Year(s)
Adjunct Professor, Department of Biochemistry, National University of Singapore 2012-present
Research Director/Professor, Institute of Molecular and Cell Biology, Singapore 2010–present
Adjunct Associate Professor, Department of Biological Sciences, National University of Singapore 2007-present
Senior Principal Investigator, Institute of Molecular and Cell Biology, Singapore 2007-2010
Senior Scientist/Principal Investigator, Institute of Molecular and Cell Biology, Singapore 2002-2007
Senior Scientist /Principal Investigator, Institute of Molecular Agrobiology, Singapore 2001-2002
Research Associate, Laboratory of Molecular Biophysics, University of Oxford, UK 2000-2001
Research Associate, Section of Structural Biology, Institute of Cancer Research, UK 1999-2000
Research Associate, Laboratory of Molecular Biophysics, University of Oxford, UK 1998-1999
Research Assistant, Protein Engineering Research Institute, Osaka, Japan. 1993-1994
Research Assistant, Institute of Biophysics, Academia Sinica, P.R. China. 1990-1993

Research Interest

* mRNA metabolism and translational control.
* Hippo signaling pathway.
* Long noncoding RNA.
* Structural based drug design.

Selected Publications

  1. Chen L, Muhlrad D, Hauryliuk V, Cheng Z, Lim MK, Shyp V, Parker R and Song H (2010) Structure of the Dom34-Hbs1 Complex and implications for No-Go decay. Nat. Struct. & Mol. Biol. 17, 1233-40.

  2. Chen L, Chan SW, Zhang X, Walsh M, Lim CJ, Hong W and Song H (2010) Structural basis of YAP recognition by TEAD4 in the Hippo pathway Genes & Development, 24, 290-300.

  3. Cheng Z, Saito K, Pisarev AV, Wada M, Pisareva VP, Pestova TV, Gajda M, Round A, Kong C, Lim M, Nakamura Y, Svergun DI, Ito K, Song H. (2009). Structural insights into eRF3 and stop codon recognition by eRF1.Genes & Development 23, 1106-1118.

  4. Loh PG, Yang HS, Walsh MA, Wang Q, Wang X, Cheng Z, Liu D, Song H. (2009). Structural basis for translational inhibition by the tumour suppressor Pdcd4. EMBO J. 28, 274-285.

  5. She, M, Decker CJ, Svergun DI, Round A, Chen N, Muhlrad D, Parker R, Song H (2008). Structural basis of Dcp2 recognition and activation by Dcp1. Mol. Cell 29, 337-349.

  6. Gao, H., Zhou, Z., Rawat, U., Huang, C., Bouakaz, L., Wang, C., Cheng, Z., Liu, Y., Zavialov, A., Gursky, R., Sanyal, S., Ehrenberg, M., Frank, J. and Song H. (2007). RF3 Induces ribosomal conformational changes responsible for the dissociation of class-I release factor. Cell 129, 929-941.