Chit Fang CHEOK

Adjunct Assistant Professor

Affiliations

Adjunct Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Principal Investigator, p53 Joint Research Lab (JRL), A*STAR.

Education

Degree and Institution Year(s)
PhD, University of Oxford, UK 2005
Bachelor, Imperial College London, UK 2001

Professional Experience

Position and Institute Year(s)
Adjunct Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS 2009 - Present
Senior Research Fellow, p53Lab, A*STAR 2009 - Present
Senior Research Fellow, Institute of Molecular and Cell Biology, A*STAR 2006 - 2009

Research Interest

My research focuses on studying the mechanisms underlying the control of ploidy levels in normal cells. In particular, I am interested in the roles of p53 and Rb in suppressing tetraploidy formation and how loss of p53 and Rb can result in uncontrolled genome reduplication in cells with impaired mitotic division. Tetraploidy cells may be precursors of aneuploidy cancer cells and are highly prevalent in many cancers. Not surprisingly, deregulated expression of chromosomal passenger proteins and mitotic regulators such as Aurora kinases, polo-kinases and survivin are the hallmarks of cancers. Using a combination of biochemical and genetic approaches, we seek to understand the exact molecular mechanisms that underlie tetraploidy formation and how cancer cells adapt to the genomic instability under these circumstances. This would help us in identifying new drug targets for therapeutic interventions.

Selected Publications

  1. Cheok, C.F.*, Dey, A, Lane, D. P. CDK inhibitors sensitize tumor cells to nutlin-induced apoptosis. Molecular Cancer Research 2007 Nov;5(11):1133-45.

  2. Cheok, C.F.* and Lane, D.P. New developments in small molecules targeting p53 pathways in anticancer therapy. Drug Development Research 2008 Dec 9;69(6):289-96.

  3. Chew, J., Biswas, S., Shreeram, S., Humaidi, Wong, E.T., Dhillion M.K., Teo, H.L., Hazra, A., Cheok, C.F., Collazo, E.L., Bulavin, V., Tergaonkar, V. Wip1 phosphatase is a negative regulator of NFkB signaling. Nature Cell Biology 2009 May;11(5):659-66. Epub 2009 Apr 19.

  4. Dey, A., Cheok, C.F., Wong, E.T., Tergaonkar, V., Lane, D.P. R-Roscovitine simultaneously targets both the p53 and NF-kB pathway and causes potentiation of TNF∝ induced apoptosis: Implications in cancer therapy. Cell Death and Differentiation 2008 Feb;15(2):263-73.

  5. Camus, S., Menendez, S., Cheok, C.F., Stevenson, L.F., Lain, S., Lane, D.P. Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6. Oncogene 2007 Jun 14;26(28):4059-70.

  6. Cheok, C.F., Wu, L., Janscak, P., Garcia, P.L., Hickson, I.D. The Bloom's syndrome helicase promotes annealing of complementary single strands of DNA. Nucleic Acids Res. 2005 Jul 15;33(12):3932-41.

  7. * = corresponding author