Takao INOUE

Assistant Professor

Affiliations

Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.

Education

Degree and Institution Year(s)
Ph. D. in Genetics, University of Washington, Seattle, Washington, USA 1999
B.S. in Biology, University of Washington, Seattle, Washington, USA 1993

Professional Experience

Position and Institute Year(s)
Assistant Professor, Dept. of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore 2009–present
Postdoctoral scholar, California Institute of Technology, USA 2000–2006
Graduate student, University of Washington, USA 1993–1999
Undergraduate research, University of Washington, USA 1992-1993

Research Interest

I am using C. elegans genetics to address important questions in biology: Major areas of interest include:

  • Wnt signaling mediated by RTK receptors Ror and Ryk.
  • Function and mechanism of mitochondrial localization.
  • Transcriptional regulation by chromatin factors and lncRNAs.

Selected Publications

  1. D. Mok, P.W. Sternberg and T. Inoue. 2015. Morphologically defined sub-stages of C. elegans vulval development in the fourth larval stage. BMC Developmental Biology, 15:26 doi:10.1186/s12861-015-0076-7

  2. J. Yang, H.T. Fong, Z. Xie, J.W.H. Tan and T. Inoue., 2015. Direct and positive regulation of C. elegans bed-3 by PRDM1/BLIMP1 ortholog BLMP-1. BBA Gene Regulatory Mechanisms, 1849(9):1229-36

  3. Y. Shen, N.P.W. Low, L.F. Ng, T. Hagen, J. Gruber and T. Inoue., 2016 C. elegans miro-1 mutation reduces the amount of mitochondria and extends life span. PLOS One. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153233

  4. W.C. Poh, Y. Shen and T. Inoue, "Function of the Ryk Intracellular Domain in C. elegans Vulval Development". Developmental Dynamics, (2014).

  5. K.Y. Goh, N.W. Ng, T. Hagen and T. Inoue, "p21-Activated kinase interacts with Wnt signaling to regulate tissue polarity and gene expression". Proceedings of the National Academy of Sciences of the United States of America, 109 (2012): 15853.

  6. T. Inoue and P.W. Sternberg, "C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis". Developmental Biology, 2010

  7. J.L. Green, T. Inoue and P.W. Sternberg, "Opposing Wnt pathways orient cell polarity during organogenesis". Cell, 134 (2008): 646-656.

  8. T. Inoue, H.S.Oz, D. Wiland, S. Gharib, D. Deshpande, R.J. Hill, W.S. Katz, and P.W. Sternberg, "C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN- 17/Frizzled in Wnt signaling". Cell. 118 (2004): 795-806.