Sudhakar JHA

Assistant Professor

+65 6601 2402
bchsjha@nus.edu.sg

Affiliations

Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Junior Principal Investigator, Cancer Biology Programme, Cancer Science Institute of Singapore.

Education

Degree and Institution Year(s)
Ph.D. School of Life Sciences, Jawaharlal Nehru University, New Delhi, India 2003
M.Sc. School of Life Sciences, Jawaharlal Nehru University, New Delhi, India 2000
B.Sc. School of Life Sciences, Jawaharlal Nehru University, New Delhi, India 1998

Professional Experience

Position and Institute Year(s)
Assistant Professor, Dept. of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore 2011 – present
Junior Principal Investigator, Cancer Science Institute of Singapore, National University of Singapore 2011 - present
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, USA 2003 - 2011

Research Interest

Down-regulation of tumor suppressors or expression of oncogenes is a hallmark feature of cancers. These alterations in the transcriptome arise as a consequence of a malfunction in the chromatin organization. Chromatin remodeling complexes play an important role in maintaining this organization as they create a histone code that is read by specific readers resulting in an active or repressed chromatin. I am interested in studying the regulation of chromatin remodeling complexes and their role in cancer prevention. My research focuses on understanding the function of TIP60 (a histone acetyltransferase) as a tumor suppressor. I have discovered TIP60 to be down-regulated by E6, a viral oncogene expressed by human papillomavirus (HPV). Interestingly, TIP60 is down-regulated in multiple cancers. Using TIP60 as a candidate molecule, I plan to investigate how deregulation of this chromatin remodeling complex can lead to cancer.

Selected Publications

  1. Abbas, T.; Shibata, E.; Park, J; Jha, S.; Karnani, N. and Dutta, A. CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation. Molecular Cell 40 (Oct 8 2010): 9-21.

  2. Jha, S.; Vande Pol, S.; Banerjee, N.S.; Dutta, A.B.; Chow, L.T. and Dutta, A. Destabilization of TIP60 by human papillomavirus E6 results in attenuation of TIP60 dependent transcriptional regulation and apoptotic pathway. Molecular Cell 38 (Jun 11 2010): 700-711. (Highlight: “Faculty of 1000 Biology”, 17th June 2010)

  3. Jha, S., and Dutta, A. RVB1/RVB2: running rings around molecular biology. Molecular Cell 34 (Jun 12 2009): 521-533.

  4. Torreira, E.; Jha, S.; Lopez-Blanco, J. R.; Arias-Palomo, E.; Chacon, P.; Canas, C.; Ayora, S.; Dutta, A.; and Llorca, O. Architecture of the pontin/reptin complex, essential in the assembly of several macromolecular complexes. Structure 16 (Oct 8 2008): 1511-1520.

  5. Jha, S.; Shibata, E.; and Dutta, A. Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage. Molecular and Cellular Biology 28 (Apr 2008): 2690-2700.

  6. Zhu, W.*; Ukomadu, C.*; Jha, S.*; Senga, T.; Dhar, S. K.; Wohlschlegel, J. A.; Nutt, L. K.; Kornbluth, S.; and Dutta, A. Mcm10 and And-1/CTF4 recruit DNA polymerase {alpha} to chromatin for initiation of DNA replication. Genes & Development 21 (Sep 15 2007): 2288-2299. *Co-first author

  7. Abbas, T.; Jha, S.; Sherman, N. E.; and Dutta, A. Autocatalytic phosphorylation of CDK2 at the activating Thr160. Cell Cycle 6 (Apr 1 2007): 843-852.

  8. Jonsson, Z. O.*; Jha, S.*; Wohlschlegel, J. A.; and Dutta, A. Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complex. Molecular Cell 16 (Nov 5 2004): 465-477. *Co-first author