Jianming JIANG

Assistant Professor

+65 6601 5180
bchjian@nus.edu.sg

Affiliations

Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.

Education

Degree and Institution Year(s)
PhD: Department of Biological Sciences, NUS and Genome Institute of Singapore, Singapore 2005-2010
MSc: Department of Biochemistry, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, China 2001-2004
BSc: Department of Biotechnology, Zhejiang University, China 1997-2001

Professional Experience

Position and Institute Year(s)
Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS 2015–present
Postdoctoral Research Associate: Department of Genetics, Harvard Medical School, USA 2010-2015

Research Interest

His current research interests include: understanding how the deregulated factors contribute to the development of cardiovascular disease using cutting-edge technologies; identifying novel regulators that reinstate the regenerative potential of cardiomyocytes in the postnatal mammalian heart.

Selected Publications

  1. Yeo J.-C., Jiang J., Tan Z.-Y., Yim G.-R., Ng J.-H., Göke J., Kraus P, Liang H., Gonzales K.A.U., Chong H.-C., Tan C.-P., Lim Y.-S., Tan N.-S., Lufkin T., Ng H.-H. (2014) Klf2 is an essential factor that sustains ground state pluripotency. Cell Stem Cell 14, 864-872.

  2. Lin Z., Gise A.v., Zhou P., Gu F., Ma Q., Jiang J., Yau A.L., Buck J.N., Gouin K.A., Gorp P.R.R.v., Zhou B., Chen J., Seidman J.G., Wang D.-Z., Pu. W.T. (2014) Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circulation Research 115, 354-363.

  3. Jiang J., Wakimoto H., Seidman J.G., Seidman C.E. (2013) Allele-specific Silencing of Mutant Myh6 transcripts in Mice Suppresses Hypertrophic Cardiomyopathy. Science 342, 111-114.

  4. Zaidi S., Choi M., Wakimoto H., Ma L., Jiang J., et al. (2013) De novo mutations in histone modifying genes in congenital heart disease. Nature 498, 220-223.

  5. Chia N.-Y., Chan Y.-S., Feng B., Lu X., Orlov Y.L., Moreau D., Kumar P., Yang L., Jiang J., et al. (2010) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature 2010, 468:316-20.

  6. Heng J.-C.D., Feng B., Han J., Jiang J., Kraus P., Ng J.-H., Orlov Y.L., Huss M., Yang L., Lufkin T., Lim B., Ng H.-H. (2010) The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell 6, 167-174.

  7. Feng B.*, Jiang J.*, Kraus P., Ng J.-H., Heng J.-C.D., Chan Y.-S., Yaw L.P., Zhang W. ,Loh Y.-H., Han J., Vega V.B., Cacheux-Rataboul V., Lim B., Lufkin T., Ng H.-H.. (2009) Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nature Cell Biology 11, 197-203. * equal first authors

  8. Jiang J., Ng. H.-H. (2008) TGFbeta and SMADs talk to NANOG in human embryonic stem cells. Cell Stem Cell 3, 127-128

  9. Chen X., Xu H,, Yuan P., Fang F., Huss M., Vega V.B., Wong E., Orlov Y.L., Zhang W., Jiang J. et al.(2008) Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133, 1106-1117

  10. Jiang J., Chan Y.-S., Loh Y.-H., Cai J., Tong G.-Q., Lim C.-A., Robson P., Zhong S., Ng H.-H. (2008) A core Klf circuitry regulates self-renewal of embryonic stem cells. Nature Cell Biology 10, 353 - 360.

  11. Yan J.*, Jiang J.* Lim C.A., Wu Q., Ng H.-H., Chin K.-C. (2007) BLIMP1 regulates cell growth through repression of p53 transcription. Proceedings of the National Academy of Sciences US 104, 1841-1846. * equal first authors