Jan GRUBER

Assistant Professor

+65 6516 4638
bchjg@nus.edu.sg

Affiliations

Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Assistant Professor, Yale-NUS.

Education

Degree and Institution Year(s)
Doctor of Philosophy in Biochemistry, University of Oxford, Laboratory of Molecular Biophysics 2000-2004
Master of Science (by Research) University of Oxford, Laboratory of Molecular Biophysics 2000
Master of Advanced Studies (Part III of the Math. Tripos) University of Cambridge, Department of Applied Mathematics and Theoretical Physics 1998-1999
Physics Vordiplom (1997) RWTH-Aachen 1996-1997

Professional Experience

Position and Institute Year(s)
Assistant Professor, Department of Biochemistry, NUS Medicine 2014–present
Assistant Professor, Yale-NUS Science Division 2014–present
Senior Research Fellow, National University of Singapore 2011-2014

Research Interest

Jan Gruber’s laboratory focuses on:

Ageing, Age-dependent dieseases, Interventions against
Basic / Molecular Mechanisms of Ageing
C. elegans as a Model Organism
Role of Mitochondria and Free Radicals in Ageing and Age-dependent Diseases
Biomarkers of Oxidative Damage
Computational Biology
Evolution of ageing

Selected Publications

  1. Ng, L.F., Gruber, J., Cheah, I.K., (...), Wenk, M.R., Halliwell, B., he mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease, FRBM, (2014), 71, pp. 390-401

  2. Ranjan, M., Gruber, J., Ng, L.F., Halliwell, B., Repression of the mitochondrial peroxiredoxin antioxidant system does not shorten life span but causes reduced fitness in C. elegans. FRBM (2013), 63, pp. 381-389

  3. Gruber, J., Ng, L.F., Fong, S., Wong, W.T., Chen, C.B., Shui, G., Chong, W.F., Schaffer, S., Wenk, M., Halliwell, B., Mitochondrial ageing in Caenorhabditis - what do we learn from superoxide dismutase knockouts?, PLoS One (2011), e19444, p.1-16

  4. Pun, P.B.L.*, Gruber, J.*, Tang, S.Y., Schaffer, S., Ong, R.L.S., Fong, S., Ng, L.F., Cheah, I., Halliwell, B., Ageing in nematodes: Do antioxidants extend lifespan in Caenorhabditis elegans?, (2010) Biogerontology, 11 (1), pp. 17-30.

  5. Gruber, J., Tang, S.Y., Jenner, A.M., Mudway, I., Blomberg, A., Behndig, A., Kasiman, K., (...), Halliwell, B. Allantoin in human plasma, serum, and nasal-lining fluids as a biomarker of oxidative stress: Avoiding artifacts and establishing real in vivo concentrations (2009) Antioxidants and Redox Signalling, 11 (8) PP. 1767 - 1776